ABSTRACT
Background: The present study was aimed to study alterations in serum levels of calcium and phosphorus levels in senile cataract patients.Methods: 25 senile cataract patients in age group of 50 to 80 years and 25 control group were included in the study. Serum Calcium and Phosphorus levels were determined by Orthocresolphthalein, Fiske SubbaRow method respectivelyResults: Significantly increased levels of serum calcium in cataract patients (11.58�65 mg/dl) were found as compared to controls (8.53�45mg/dl) (p<0.0001). Serum phosphorus concentration in cataract patients (5.28�46 mg/dl) were significantly increased when compared to controls (3.02�23mg/dl) (p<0.0001).Conclusions: Presence of G-protein receptors in lens leads to the release of intracellular calcium. As total calcium in the lens increases, we hypothesize that higher intercellular calcium concentrations, coupled with decreased Ca2+-ATPase activity and greater membrane permeability could lead to elevated free intracellular calcium levels causing cataract. So, abnormal elevation of serum calcium and phosphorus can be used as a marker for prevention of age-related human cataract.
ABSTRACT
Prevalence of hypothyroidism and its subsequent cardiometabolic complications is on exponential rise. CRP is raised in hypothyroid patients long before other metabolic derangements of hypothyroidism take place and may be a common Patho physiological factor tying together various components of cardiometabolic dysfunction. Present study was aimed at evaluating the role of CRP as an additional cardiovascular risk marker in hypothyroid patients. Methods: 46 diagnosed hypothyroid patients and 46 age and sex matched healthy controls were included in this study. Participants were evaluated based on detailed history, clinical examination and laboratory investigations. Blood samples were collected after overnight fast. Serum T3, T4, TSH, Total Cholesterol (TC), Triglycerides (TG), HDL Cholesterol (HDL-C), VLDL Cholesterol (VLDL-C), LDL Cholesterol (LDL-C) and CRP were estimated. Results were analyzed by unpaired t-test, P-value was determined & Correlation coefficient was calculated amongst various parameters. Results: Statistically significant increased levels of serum TSH, total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, VLDL cholesterol and CRP in hypothyroid patients as compared with control were observed. We found decreased levels of serum T3 and T 4 in hypothyroid patients as compared with control. Conclusions: An atherogenic lipid profile along with inflammation in patients with hypothyroidism predispose them to cardiovascular disease. Study suggests CRP; a simple, sensitive & independent cardiovascular risk predictor in hypothyroid patients with a potential to reveal hidden burden of metabolic dysfunction and offers a hope that, cardiovascular event can be well prevented with appropriate interventions.
ABSTRACT
Suicidal tendencies are one of the major social problems worldwide. It is equally seen in Indian population. Organo-phosphorus compounds are usually preferred because of their easy availability. Paraquat is one of the lesser known herbicide agent, which is not an OP compound. It is highly toxic and causes damage to the lungs, liver and kidneys. Occurrence of paraquat poisoning is rare, but has very high mortality rate. Here we report one such case which was earlier misdiagnosed as organo-phosphorus poisoning, but diagnosed later by qualitative urine sodium dithionite test. It is a simple test for early diagnosis of paraquat poisoning. It is recommended to performing this test in all suspected cases of oral poisoning.